Intestinal Permeability Assessment Leaky Gut Genova Lab

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Sample Type: Urine

The Intestinal Permeability Assessment is a powerful and noninvasive assessment of small intestinal absorption and barrier function in the bowel. The small intestine uniquely functions as a digestive/absorptive organ for nutrients, as well as a powerful immune and mechanical barrier against excessive absorption of bacteria, food antigens, and other macromolecules. Both malabsorption and increased intestinal permeability(i.e.leaky gut) are associated with chronic gastrointestinal imbalances, as well as many systemic disorders.

Leaky gut syndrome is an underlying problems relating to numerous digestive problems. Take this simple urine test today and learn more about the causes of your digestive discomfort.

*Labs are not processed from New York state.

Increased permeability of the small intestine can:

    • Increase the number of foreign compounds entering the bloodstream.

    • Allow bacterial antigens capable of cross-reacting with host tissue to enter the bloodstream, leading to auto-immune processes.

  • Enhance the uptake of toxic compounds that can overwhelm the hepatic detoxification system and lead to an overly sensitized immune system.

Increased gut permeability has been observed in a range of disorders such as:

    • Inflammatory Bowel Disease (IBD)

    • Food allergy

    • Inflammatory joint disease

  • Chronic dermatologic conditions

Studies have demonstrated that the increased permeability observed in patients with ankylosing spondylitis, rheumatoid arthritis, and vasculitis may be an important factor in thepathogenesis of these disorders. Decreased permeability, on the other hand, appears as a fundamental cause of malabsorption, subsequent malnutrition, and failure to thrive.

In certain disease states of the small intestine, such as gluten-sensitive enteropathy, permeability to large molecules may increase, while permeability to small molecules decreases, a result of damage to the microvilli. As a result, nutrients become even less available to assist in the detoxification of antigens flooding the system.

Possible causes of intestinal permeability include:

    • Intestinal infection

    • Ingestion of allergenic foods or toxic chemicals

    • Deficient secretory IgA

    • Trauma and endotoxemia

  • NSAIDs

Testing Procedure:
The Intestinal Permeability Assessment directly measures the ability of two non-metabolized sugar molecules to permeate the intestinal mucosa. The patient drinks a premeasured amount of lactulose and mannitol. The degree of intestinal permeability or malabsorption is reflected in the levels of the two sugars recovered in a urine sample collected over the next 6 hours.

Analytes:
A measurement of urinary clearance of the challenge substances lactulose and mannitol, and lactulose/mannitol ratio.

Specimen Requirements:
15cc urine (before drink), 15ccaliquot of 6-hour urine (after drink)

Before Patient Takes this Test:

  • Make sure fasting glucose level is not high
  • Inform practitioner about medication use

  • Do not eat or drink anything for 8 hours

Intestinal Permeability Sample Report 

More Information
Patient Name N/A
Patient Birth Date N/A
Manufacturer Genova Labs
Description

Increased permeability of the small intestine can:

    • Increase the number of foreign compounds entering the bloodstream.

    • Allow bacterial antigens capable of cross-reacting with host tissue to enter the bloodstream, leading to auto-immune processes.

  • Enhance the uptake of toxic compounds that can overwhelm the hepatic detoxification system and lead to an overly sensitized immune system.

Increased gut permeability has been observed in a range of disorders such as:

    • Inflammatory Bowel Disease (IBD)

    • Food allergy

    • Inflammatory joint disease

  • Chronic dermatologic conditions

Studies have demonstrated that the increased permeability observed in patients with ankylosing spondylitis, rheumatoid arthritis, and vasculitis may be an important factor in thepathogenesis of these disorders. Decreased permeability, on the other hand, appears as a fundamental cause of malabsorption, subsequent malnutrition, and failure to thrive.

In certain disease states of the small intestine, such as gluten-sensitive enteropathy, permeability to large molecules may increase, while permeability to small molecules decreases, a result of damage to the microvilli. As a result, nutrients become even less available to assist in the detoxification of antigens flooding the system.

Possible causes of intestinal permeability include:

    • Intestinal infection

    • Ingestion of allergenic foods or toxic chemicals

    • Deficient secretory IgA

    • Trauma and endotoxemia

  • NSAIDs

Testing Procedure:
The Intestinal Permeability Assessment directly measures the ability of two non-metabolized sugar molecules to permeate the intestinal mucosa. The patient drinks a premeasured amount of lactulose and mannitol. The degree of intestinal permeability or malabsorption is reflected in the levels of the two sugars recovered in a urine sample collected over the next 6 hours.

Analytes:
A measurement of urinary clearance of the challenge substances lactulose and mannitol, and lactulose/mannitol ratio.

Specimen Requirements:
15cc urine (before drink), 15ccaliquot of 6-hour urine (after drink)

Before Patient Takes this Test:

  • Make sure fasting glucose level is not high
  • Inform practitioner about medication use

  • Do not eat or drink anything for 8 hours

Intestinal Permeability Sample Report 

Short Description

Sample Type: Urine

The Intestinal Permeability Assessment is a powerful and noninvasive assessment of small intestinal absorption and barrier function in the bowel. The small intestine uniquely functions as a digestive/absorptive organ for nutrients, as well as a powerful immune and mechanical barrier against excessive absorption of bacteria, food antigens, and other macromolecules. Both malabsorption and increased intestinal permeability(i.e.leaky gut) are associated with chronic gastrointestinal imbalances, as well as many systemic disorders.

Leaky gut syndrome is an underlying problems relating to numerous digestive problems. Take this simple urine test today and learn more about the causes of your digestive discomfort.

*Labs are not processed from New York state.

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Product Questions

Headquartered in Asheville, NC, Genova Diagnostics is a global leader in functional laboratory testing and a pioneer in innovative new approaches to personalized medicine. Unlike traditional labs that focus on disease pathology, Genova offers comprehensive panels that combine standard and innovative biomarkers to provide a more complete understanding of specific biological systems. As more patients take an active role in managing their health, and clinicians focus on prevention, these diagnostic tests provide a more complete picture of health and help identify problems before chronic conditions and diseases develop. Color graphic reports facilitate physician-patient communication and development of a personalized approach to optimal health. The internationally renowned lab is committed to the highest professional standards and has a team of medical experts who provide consultation to healthcare professionals, as well as a robust array of educational resources.

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